On the interactions of lipids and proteins in the red blood cell membrane

The effects of temperature and of the action of a purified phospholipase C enzyme preparation on human red blood cell membranes has been investigated by chemical analyses, circular dichroism, and proton magnetic resonance measurements. The results indicate that a substantial fraction of the phospholipids and the proteins of the membranes can change structure independently of one another, suggesting a mosaic pattern for the organization of the lipids and proteins in membranes

Report of the Stanford Linked Data Workshop

The Stanford University Libraries and Academic Information Resources (SULAIR) with the Council on Library and Information Resources (CLIR) conducted at week-long workshop on the prospects for a large scale, multi-national, multi-institutional prototype of a Linked Data environment for discovery of and navigation among the rapidly, chaotically expanding array of academic information resources. As preparation for the workshop, CLIR sponsored a survey by Jerry Persons, Chief Information Architect emeritus of SULAIR that was published originally for workshop participants as background to the workshop and is now publicly available. The original intention of the workshop was to devise a plan for such a prototype. However, such was the diversity of knowledge, experience, and views of the potential of Linked Data approaches that the workshop participants turned to two more fundamental goals: building common understanding and enthusiasm on the one hand and identifying opportunities and challenges to be confronted in the preparation of the intended prototype and its operation on the other. In pursuit of those objectives, the workshop participants produced:1. a value statement addressing the question of why a Linked Data approach is worth prototyping;2. a manifesto for Linked Libraries (and Museums and Archives and …);3. an outline of the phases in a life cycle of Linked Data approaches;4. a prioritized list of known issues in generating, harvesting & using Linked Data;5. a workflow with notes for converting library bibliographic records and other academic metadata to URIs;6. examples of potential “killer apps” using Linked Data: and7. a list of next steps and potential projects.This report includes a summary of the workshop agenda, a chart showing the use of Linked Data in cultural heritage venues, and short biographies and statements from each of the participants

Downbeat nystagmus: aetiology and comorbidity in 117 patients

Objectives: Downbeat nystagmus (DBN) is the most common form of acquired involuntary ocular oscillation overriding fixation. According to previous studies, the cause of DBN is unsolved in up to 44% of cases. We reviewed 117 patients to establish whether analysis of a large collective and improved diagnostic means would reduce the number of cases with ``idiopathic DBN'' and thus change the aetiological spectrum.Methods: The medical records of all patients diagnosed with DBN in our Neurological Dizziness Unit between 1992 and 2006 were reviewed. In the final analysis, only those with documented cranial MRI were included. Their workup comprised a detailed history, standardised neurological, neuro-otological and neuro-ophthalmological examination, and further laboratory tests.Results: In 62% (n = 72) of patients the aetiology was identified (``secondary DBN''), the most frequent causes being cerebellar degeneration (n = 23) and cerebellar ischaemia (n = 10). In 38% (n = 45), no cause was found (``idiopathic DBN''). A major finding was the high comorbidity of both idiopathic and secondary DBN with bilateral vestibulopathy (36%) and the association with polyneuropathy and cerebellar ataxia even without cerebellar pathology on MRI.Conclusions: Idiopathic DBN remains common despite improved diagnostic techniques. Our findings allow the classification of ``idiopathic DBN'' into three subgroups: ``pure'' DBN (n = 17); ``cerebellar'' DBN (ie, DBN plus further cerebellar signs in the absence of cerebellar pathology on MRI; n = 6); and a ``syndromatic'' form of DBN associated with at least two of the following: bilateral vestibulopathy, cerebellar signs and peripheral neuropathy (n = 16). The latter may be caused by multisystem neurodegeneration

The relationship between cognitive moral development and attitudes toward cheating among preservice and in-service high school teachers

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Success in unity : John Corigliano\u27s score to The red violin (1999)

A thesis submitted in partial fulfillment of the requirements for the degree of Bachelor of Arts with Honors in Music from the College of William and Mary in Virginia

Software Requirements Specification for Lunar Icecube

A thesis presented to the faculty of the College of Science at Morehead State University in partial fulfillment of the requirements for the Degree Master of Science by Michael R. Glaser-Garbrick on April 21, 2017

Tracing Real-Time Transnational Hydrologic Sensitivity and Crop Irrigation in the Upper Rhine Area over the Exceptional Drought Episode 2018–2020 Using Open Source Sentinel-2 Data

Climate and regional land-use and landcover change (LUCC) impact the ecosystem of the Upper Rhine Area (URA) and transform large parts of the landscape into strongly irrigated agricultural cropland. The increase of long-term drought periods and the trend towards low summer precipitation totals trigger an increase in groundwater scarcity and amplify the negative effects of extensive irrigation purposes and freshwater consumption in a hydrologically sensitive region in Central Europe. This article presents qualitative transnational open source remote sensing temporal series of vegetation indices (NDVI) and groundwater level development to tracing near real-time vegetation change and socio-ecological feedbacks during periods of climate extremes in the Upper Rhine Area (2018–2020). Increased freshwater consumption caused a dramatic drop in groundwater availability, which eventually led to a strong degradation of the vegetation canopy and caused governmental regulations in July 2020. Assessing vegetation growth behavior and linking groundwater reactions in the URA through open source satellite data contributes to a rapidly accessible understanding of the ecosystem’s feedbacks on the local to the transnational scale and further enables risk management and eco-political regulations in current and future decisionmaking processes.Climate and regional land-use and landcover change (LUCC) impact the ecosystem of the Upper Rhine Area (URA) and transform large parts of the landscape into strongly irrigated agricultural cropland. The increase of long-term drought periods and the trend towards low summer precipitation totals trigger an increase in groundwater scarcity and amplify the negative effects of extensive irrigation purposes and freshwater consumption in a hydrologically sensitive region in Central Europe. This article presents qualitative transnational open source remote sensing temporal series of vegetation indices (NDVI) and groundwater level development to tracing near real-time vegetation change and socio-ecological feedbacks during periods of climate extremes in the Upper Rhine Area (2018–2020). Increased freshwater consumption caused a dramatic drop in groundwater availability, which eventually led to a strong degradation of the vegetation canopy and caused governmental regulations in July 2020. Assessing vegetation growth behavior and linking groundwater reactions in the URA through open source satellite data contributes to a rapidly accessible understanding of the ecosystem’s feedbacks on the local to the transnational scale and further enables risk management and eco-political regulations in current and future decisionmaking processes

Flupenthixol in relapse prevention in schizophrenics with comorbid alcoholism: Results from an open clinical study

Substance use, especially alcoholism, has been recognized as a significant problem in schizophrenic patients, though only a few studies on the effects of pharmacotherapy in these patients have been conducted so far. The thioxanthene neuroleptic flupenthixol, which can be given intramuscularly (i.m.) for improving compliance, has been studied as a possible anti-craving drug both in animal models of alcoholism and some clinical studies. Pilot studies suggest that comorbid schizophrenics with substance use may benefit from treatment with flupenthixol. Efficacy of flupenthixol (10-60 mg i.m.) in reducing alcohol consumption of dual diagnosis patients was studied in an open 6-month clinical trial in 27 schizophrenics with comorbid alcoholism. Twenty-one patients entered the intention-to-treat analysis. Fourteen subjects were completers, 13 dropped out. Six patients completely abstained from alcohol during treatment. Alcohol consumption was significantly reduced compared to baseline (4 weeks before treatment as measured by timeline follow-back interview). In general, while patients showed a marked improvement concerning alcohol consumption, only a slight improvement in psychopathology was recorded. Overall tolerability was good. These data indicate a probable beneficial effect of flupenthixol in schizophrenic patients with comorbid alcoholism. Although the efficacy of flupenthixol as an anti-craving drug in dual diagnosis patients has to be explored in further studies, the drug may be considered a promising medication for these patients. Copyright (C) 2003 S. Karger AG, Basel